Khwaja Qamaruddin Sialvi was born on 24 Jumada al-awwal 1324 A.H. (7 July 1906), in Sial Sharif in the Punjab Province of British India. He was the eldest son of Hazrat Zia-ud-din Sialvi. He was familiar with the Quran by the age of nine. He received his religious education at several institutions, including ones in Mecca and Ajmer.
After completing his education, Sialvi tenaciously opposed British rule in India, and worked hard for the establishment of a state for the Muslims of India. The British were displeased that he was working against them and offered him the title of "His Holiness", the highest spiritual title in the British Raj, for giving up his opposition. Sialvi turned down the offer and burnt the letter conveying it to ashes.
Sialvi became the president of the Sargodha branch of the Muslim League. He went to all corners of subcontinent to vote for the Muslim League in the election of 1946. He particularly walked along with Pir of Zakori in North-West Frontier Province to vote for the independence of Pakistan in the referendum of 1947. After the inception of Pakistan, he wrote to Quaid-e-Azam to congratulate him and emphasize the need for promulgation of Islamic laws. Replying his letter Quaid-e-Azam wrote "Efforts on part of Mashaikhs in the Pakistan Movement are highly commendable. Rest assured Islamic laws will be promulgated in Pakistan."In the Indo-Pakistani War of 1965, Sialvi donated all the ornaments of his family to the Pakistan Army. In 1970 he became the president of Jamiat Ulema-i-Pakistan (JUP) and under his leadership party won eighteen seats in the National Assembly. Under his leadership, the party fared very well in the election of 1970. He was twice nominated as a member of the Islamic Ideology Council, where he worked hard to Islamicize the existing laws.
Sialvi was awarded Tamgha-e-Imtiaz (Medal of Excellence), the fourth-highest award of Pakistan, by the president of Pakistan in 1981. He died in a road accident on July 20, 1981 (17th Ramadan)